Folic Acid Research Today is a free monthly online journal that collates and summarizes the latest research about Folic Acid, including details on folate, deficiency, pregnancy, benefits, sources, side-effects.

WITHDRAWN: Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects.

Lumley J, Watson L, Watson M, Bower C

Mother and Child Health Research, La Trobe University, 324-328 Little Lonsdale Street, Melbourne, Victoria, Australia, 3000.

Published 14 April 2011 in Cochrane Database Syst Rev, 4: CD001056.
Full-text of this article is available online (may require subscription).

Articles on Folic Acid published 15 March 2011:

U.S. provider reported folic acid or multivitamin ordering for non-pregnant women of childbearing age: NAMCS and NHAMCS, 2005-2006.   Matern Child Health J, 15(3): 352-9.

Folic acid use started prior to pregnancy confers a decreased risk of neural tube defects, and yet 20-50% of pregnancies are unplanned. We sought to determine whether medical providers order folic acid (FA) or folic acid-containing multivitamins (MVI) for their non-pregnant female patients of childbearing age. This is a cross-sectional study using data from the CDC's National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS) (2005 and 2006). ... [Abstract] [Full-text]

Articles on Folic Acid published 1 March 2011:

Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death.   Toxicol Appl Pharmacol, 251(3): 217-25.

Homocysteine is an excitatory amino acid implicated in multiple diseases including amyotrophic lateral sclerosis (ALS). Information on the toxicity of homocysteine in motor neurons is limited and few studies have examined how this toxicity can be modulated. In NSC-34D cells (a hybrid cell line derived from motor neuron-neuroblastoma), homocysteine induces apoptotic cell death in the millimolar range with a TC₅₀ (toxic concentration at which 50% of maximal cell death is achieved) of 2.2 mM, ... [Abstract] [Full-text]

Articles on Folic Acid published 17 February 2011:

Folate supplementation differently affects uracil content in DNA in the mouse colon and liver.   Br J Nutr, 105(5): 688-93.

High folate intake may increase the risk of cancer, especially in the elderly. The present study examined the effects of ageing and dietary folate on uracil misincorporation into DNA, which has a mutagenic effect, in the mouse colon and liver. Old (18 months; n 42) and young (4 months; n 42) male C57BL/6 mice were pair-fed with four different amino acid-defined diets for 20 weeks: folate deplete (0 mg/kg diet); folate replete (2 mg/kg diet); folate supplemented (8 mg/kg diet); folate deplete ... [Abstract] [Full-text]

Articles on Folic Acid published 25 January 2011:

A validated ultra high pressure liquid chromatographic method for qualification and quantification of folic acid in pharmaceutical preparations.   J Pharm Biomed Anal, 54(5): 995-1000.

A fully validated UHPLC method for the identification and quantification of folic acid in pharmaceutical preparations was developed. The starting conditions for the development were calculated starting from the HPLC conditions of a validated method. These start conditions were tested on four different UHPLC columns: Grace Vision HT™ C18-P, C18, C18-HL and C18-B (2 mm × 100 mm, 1.5 μm). After selection of the stationary phase, the method was further optimised by testing two aqueous and two ... [Abstract] [Full-text]

Articles on Folic Acid published 21 January 2011:

High intake of folate from food sources is associated with reduced risk of esophageal cancer in an Australian population.   J Nutr, 141(2): 274-83.

Folate plays a key role in DNA synthesis and methylation. Limited evidence suggests high intake may reduce risks of esophageal cancer overall; however, associations with esophageal cancer subtypes and Barrett's esophagus (BE), a precancerous lesion, remain unexplored. We evaluated the relation between intake of folate, B vitamins, and methyl-group donors (methionine, choline, betaine) from foods and supplements, polymorphisms in key folate-metabolizing genes, and risk of BE, esophageal ... [Abstract] [Full-text]

Articles on Folic Acid published 19 January 2011:

Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.   J Pharmacol Exp Ther, 336(2): 336-43.

During a phase I trial of EC145 (a folate-targeted vinca alkaloid conjugate), constipation was identified as the dose-limiting toxicity, probably from a nonfolate receptor-related liver clearance process capable of releasing unconjugated vinca alkaloid from EC145 and shuttling it to the bile. Here, we report on the selective placement of novel carbohydrate segments (1-amino-1-deoxy-glucitolyl-γ-glutamate) spaced in-between the folate and vinca alkaloid moieties of EC145, which yielded a new ... [Abstract] [Full-text]

Articles on Folic Acid published 17 January 2011:

Irradiation is useful for manufacturing ready-to-eat cooked meat products enriched with folic acid.   Meat Sci, 87(4): 330-5.

Cooked sausages enriched with folic acid (0.6, 1.2 and 2.4 mg/100 g) were manufactured as ready-to-eat (RTE) products using E-beam radiation (2-4 kGy) as a non-thermal technology. The effects of this treatment on the folic acid content, colour, texture and sensory properties of the final products were studied. The characteristics of sausages were not affected by the presence of folic acid, independently of the amount added, and their overall acceptability was good. Doses of 4 kGy caused losses ... [Abstract] [Full-text]

Articles on Folic Acid published 11 January 2011:

Do novel risk biomarkers reflect the severity of peripheral arterial disease?   Angiology, 62(2): 126-33.

The association between novel atherosclerotic risk biomarkers and severity of peripheral arterial disease (PAD) was assessed. Patients (n = 133) with PAD were recruited. Established risk biomarkers including low- and high-density cholesterol, triglycerides, and blood pressure were measured. Novel risk biomarkers including plasma C-reactive protein, von Willebrand factor (vWF), interleukin 6, red cell folate (RCF), vitamin B12, total homocysteine (tHcy), and Hcy genotypes were also determined. ... [Abstract] [Full-text]

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