Folic Acid Research Today is a free monthly online journal that collates and summarizes the latest research about Folic Acid, including details on folate, deficiency, pregnancy, benefits, sources, side-effects.

High-Level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112.

Santos F, Wegkamp A, de Vos WM, Smid EJ, Hugenholtz J

Kluyver Centre for Genomics of Industrial Fermentation, TI Food and Nutrition, and NIZO food research, Kernhemseweg 2, P.O. Box 20, 6710 BA Ede, The Netherlands.

We observed that Lactobacillus reuteri JCM1112 produces B(12) and folate. However, the folate/B(12) mass ratio found was far below that desired for human consumption ( approximately 170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production.

Published 12 May 2008 in Appl Environ Microbiol, 74(10): 3291-4.
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